BRL.8988 (Talampicillin), a Well-Absorbed Oral Form of Ampicillin
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چکیده
منابع مشابه
BRL.8988 (talampicillin), a well-absorbed oral form of ampicillin.
The phthalidyl ester (BRL.8988, talampicillin) of ampicillin gave serum levels in man two and a half times those obtained with ampicillin itself.
متن کاملBioavailability of bacampicillin and talampicillin, two oral prodrugs of ampicillin.
A 200-mg amount of bacampicillin showed a significantly higher relative extent of bioavailability than did a 250-mg amount of talampicillin, possibly due to their different stability in the digestive juices.
متن کاملTalampicillin: a new derivative of ampicillin.
Talampicillin is a thiazolide carboxylic ester of ampicillin and is hydrolysed in the intestinal mucosa to release free ampicillin. The mean peak serum concentration of ampicillin occurred one hour after a dose of talampicillin and was about twice that attained by an equivalent dose of ampicillin. The presence of food in the stomach reduced and delayed the peak blood levels but did not affect t...
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Bacampicillin (proposed international nonproprietary name), 1'-ethoxycarbonyloxyethyl 6-(d-alpha-aminophenylacetamido)penicillanate, is a new orally well-absorbed penicillin, highly active in vivo due to rapid transformation into ampicillin. The compound is stable in vitro at gastric pH and hydrolyzed slowly to ampicillin at neutral pH but very rapidly in the presence of biological fluids, e.g....
متن کاملAmpicillin concentrations in human dental granuloma after a single oral administration of talampicillin.
Ampicillin concentrations in human serum and dental granulomas of 31 patients were determined after a single oral dose of talampicillin (equivalent to 500 mg of ampicillin) was administered to each. The specimens were taken at 1.5, 2.0, 2.5, 3.0, and 3.5 h after the administration of talampicillin. The mean peak ampicillin concentrations in serum and dental granulomas occurred at identical time...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1974
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.5.6.670